DNA nanomechanics: How proteins deform the double helix
نویسندگان
چکیده
منابع مشابه
DNA nanomechanics: how proteins deform the double helix.
It is a standard exercise in mechanical engineering to infer the external forces and torques on a body from a given static shape and known elastic properties. Here we apply this kind of analysis to distorted double-helical DNA in complexes with proteins: We extract the local mean forces and torques acting on each base pair of bound DNA from high-resolution complex structures. Our analysis relie...
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INTRODUCTION......... . ...... ................. .. ................. . .... . . ................. ......... 933 NOTIONS ABOUT RECOGNITION..... ................ . . .............. . . ..... . ......... . . ..... 934 THE HTH MOTIF... ..... ....... ................. .. . ................ .... . . .... ........... . .. . ..... .. 936 STRUCTURES.... . . . ..... .. ......... . . ................ ......
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The Saccharomyces cerevisiae CDC43 gene product is involved in establishing cell polarity during the cell-division cycle. When grown at restrictive temperatures, temperature-sensitive cdc43 mutants are unable to form buds and display delocalized cell-surface deposition [Adams et al., J. Cell Biol. (1990) in press]. We have isolated a cdc43-complementing plasmid from a yeast genomic-DNA library ...
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ژورنال
عنوان ژورنال: The Journal of Chemical Physics
سال: 2009
ISSN: 0021-9606,1089-7690
DOI: 10.1063/1.3082157